Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) associates with a considerable high rate of mortality and …

The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

There is an exciting increase of evidence that members of the disintegrin and
metalloprotease (ADAM) family critically regulate cell adhesion, migration, development and …

ADAM17, a prominent member of the 'Disintegrin and Metalloproteinase'(ADAM) family,
controls vital cellular functions through cleavage of transmembrane substrates. Here we …

ADAM metalloproteinase disintegrins have emerged as the major proteinase family that
mediates ectodomain shedding, the proteolytic release of extracellular domains from their …

Summary Background: Platelet glycoprotein (GP) VI that binds collagen, and GPIb–IX–V that
binds von Willebrand factor, initiate thrombus formation. Objectives: In this study, we …

The amyloid cascade hypothesis is the most accepted explanation for the pathogenesis of
Alzheimer's disease (AD). APP is the precursor of the amyloid β peptide (Aβ), the principal …

Ectodomain shedding is a proteolytic mechanism by which transmembrane molecules are
converted into a soluble form. Cleavage is mediated by metalloproteases and proceeds in a …

Tumor necrosis factor α-converting enzyme (TACE/ADAM17) has been implicated in the
inducible shedding of numerous cell surface proteins. In light of this, the regulation of TACE …

An important, irreversible step in many signalling pathways is the shedding of membrane-
anchored proteins. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major …