Adult-onset type 1 diabetes: current understanding and challenges

RD Leslie, C Evans-Molina, J Freund-Brown… - Diabetes …, 2021 - Am Diabetes Assoc
Recent epidemiological data have shown that more than half of all new cases of type 1
diabetes occur in adults. Key genetic, immune, and metabolic differences exist between …

Consensus guidance for monitoring individuals with islet autoantibody–positive pre-stage 3 type 1 diabetes

M Phillip, P Achenbach, A Addala… - Diabetes …, 2024 - diabetesjournals.org
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at
the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay …

Management of latent autoimmune diabetes in adults: a consensus statement from an international expert panel

R Buzzetti, T Tuomi, D Mauricio, M Pietropaolo… - Diabetes, 2020 - Am Diabetes Assoc
A substantial proportion of patients with adult-onset diabetes share features of both type 1
diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically …

Adult-onset autoimmune diabetes

R Buzzetti, E Maddaloni, J Gaglia, RD Leslie… - Nature reviews Disease …, 2022 - nature.com
Adult-onset autoimmune (AOA) diabetes pathophysiology starts with immune changes,
followed by dysglycaemia and overt disease. AOA diabetes can occur as classic type 1 …

PD-1 and PD-L1 Expression in Peripheral CD4/CD8+ T Cells Is Restored in the Partial Remission Phase in Type 1 Diabetes

X Li, T Zhong, R Tang, C Wu, Y Xie… - The Journal of Clinical …, 2020 - academic.oup.com
Context Partial remission (PR) in type 1 diabetes (T1D) is accompanied by downregulation
of the immune response. Programmed cell death-1 (PD-1) and its ligand (PD-L1) are …

Past, present and future of latent autoimmune diabetes in adults

B Liu, Y Xiang, Z Liu, Z Zhou - Diabetes/metabolism research …, 2020 - Wiley Online Library
Latent autoimmune diabetes in adults (LADA) is the most common form of autoimmune
diabetes diagnosed in adults. Similar to type 1 diabetes, the prevalence of LADA is impacted …

Prognosis and outcome of latent autoimmune diabetes in adults: T1DM or T2DM?

Z Zhou, M Xu, P Xiong, J Yuan, D Zheng… - Diabetology & Metabolic …, 2024 - Springer
Abstract Latent Autoimmune Diabetes in Adults (LADA) is a type of diabetes mellitus often
overlooked in clinical practice for its dual resemblance to Type 1 Diabetes Mellitus (T1DM) …

Frequency, clinical characteristics, and determinants of partial remission in type 1 diabetes: Different patterns in children and adults

T Zhong, R Tang, Y Xie, F Liu, X Li… - Journal of …, 2020 - Wiley Online Library
Background Partial remission (PR) is a special stage in type 1 diabetes (T1D). The different
patterns of PR frequency, characteristics, and determinants in juvenile and adult patients are …

Islet function and insulin sensitivity in latent autoimmune diabetes in adults taking sitagliptin: a randomized trial

L Yang, H Liang, X Liu, X Wang… - The Journal of …, 2021 - academic.oup.com
Context The long-term effects of dipeptidyl peptidase-4 inhibitors on β-cell function and
insulin sensitivity in latent autoimmune diabetes in adults (LADA) are unclear. Objective To …

[HTML][HTML] Adult-onset type 1 diabetes: a changing perspective

J Burahmah, D Zheng, RD Leslie - European Journal of Internal Medicine, 2022 - Elsevier
Type 1 diabetes most commonly presents in adulthood, contrary to the widely held view that
it is a disease of childhood. Furthermore, a substantial proportion of cases of adult-onset …