Estradiol (E2) is a major hormone controlling women fertility, in particular folliculogenesis.
This steroid, which is locally produced by granulosa cells (GC) within ovarian follicles …

Ovarian granulosa cells (GCs) are the most important source of estrogen. Therefore,
aromatase (estrogen synthase), which is the key enzyme in estrogen synthesis, is not only …

D-chiro-inositol (DCI) is a natural compound detectable in cell membranes, which is highly
conserved as a biological signaling molecule. In mammals, its function is primarily …

Background Hormonal therapies are commonly prescribed to patients with metastatic
granulosa cell tumours (GCT), based on high response rates in small retrospective studies …

Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile
subtype. They have a generally good prognosis, but the survival rate drastically declines in …

Omentin (ITLN1) is a novel adipokine mainly expressed in the white adipose tissue. It plays
a crucial role in the metabolic homeostasis and insulin sensitivity. Our last study …

Granulosa cell tumor (GCT) is a form of ovarian tumor characterized by its tendency to recur
years after surgical ablation. Little is known about the mechanisms involved in GCT …

Adult-type granulosa cell tumors (aGCT) are rare ovarian sex cord tumors with few effective
treatments for recurrent disease. The objective of this study was to characterize the tumor …

Objective Adult-type ovarian granulosa cell tumors (AGCTs) are hormonally active
neoplasms with limited epidemiological data available. We evaluated the effect of parity and …

Simple Summary In the past decades, the survival of ovarian malignant tumors has been
largely unchanged. Treatment usually consists of a combination of systemic and surgical …