Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

The conserved polymerase-associated factor 1 complex (Paf1C) plays multiple roles in
chromatin transcription and genomic regulation. Paf1C comprises the five subunits Paf1 …

Eukaryotic chromatin is a highly dynamic structure with essential roles in virtually all DNA-
dependent cellular processes. Nucleosomes are a barrier to DNA access, and during DNA …

Abstract Anti-silencing function 1 (Asf1) and Chromatin Assembly Factor 1 (CAF-1)
chaperone histones H3/H4 during the assembly of nucleosomes on newly replicated DNA …

The histone chaperone Chromatin Assembly Factor 1 (CAF-1) deposits tetrameric (H3/H4) 2
histones onto newly-synthesized DNA during DNA replication. To understand the …

Histone chaperones–structurally diverse, non-catalytic proteins enriched with acidic
intrinsically disordered regions (IDRs)–protect histones from spurious nucleic acid …

Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the maternal
storage and zygotic release of histones H2A/H2B. Npm contains a pentameric N-terminal …

Eukaryotic chromatin is a complex yet dynamic structure, which is regulated in part by the
assembly and disassembly of nucleosomes. Key to this process is a group of proteins …