[HTML][HTML] Single-mitosis dissection of acute and chronic DNA mutagenesis and repair
PA Ginno, H Borgers, C Ernst, A Schneider, M Behm… - Nature Genetics, 2024 - nature.com
How chronic mutational processes and punctuated bursts of DNA damage drive evolution of
the cancer genome is poorly understood. Here, we demonstrate a strategy to disentangle …
the cancer genome is poorly understood. Here, we demonstrate a strategy to disentangle …
[HTML][HTML] Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes
Characterizing somatic mutations in the brain is important for disentangling the complex
mechanisms of aging, yet little is known about mutational patterns in different brain cell …
mechanisms of aging, yet little is known about mutational patterns in different brain cell …
Sperm sequencing reveals extensive positive selection in the male germline
Mutations that occur in the cell lineages of sperm or eggs can be transmitted to offspring. In
humans, positive selection of driver mutations during spermatogenesis is known to increase …
humans, positive selection of driver mutations during spermatogenesis is known to increase …