[HTML][HTML] Single-mitosis dissection of acute and chronic DNA mutagenesis and repair

PA Ginno, H Borgers, C Ernst, A Schneider, M Behm… - Nature Genetics, 2024 - nature.com
How chronic mutational processes and punctuated bursts of DNA damage drive evolution of
the cancer genome is poorly understood. Here, we demonstrate a strategy to disentangle …

[HTML][HTML] Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes

J Ganz, LJ Luquette, S Bizzotto, MB Miller, Z Zhou… - Cell, 2024 - cell.com
Characterizing somatic mutations in the brain is important for disentangling the complex
mechanisms of aging, yet little is known about mutational patterns in different brain cell …

Sperm sequencing reveals extensive positive selection in the male germline

MDC Neville, ARJ Lawson, R Sanghvi, F Abascal… - medRxiv, 2024 - medrxiv.org
Mutations that occur in the cell lineages of sperm or eggs can be transmitted to offspring. In
humans, positive selection of driver mutations during spermatogenesis is known to increase …