Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …

In the decade since the discovery of the innate immune cyclic GMP–AMP synthase (cGAS)–
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS–STING) signaling
pathway, as vital component of innate immune system, acts a vital role in distinguishing …

STING-associated vasculopathy with onset in infancy (SAVI) is a type I interferonopathy
caused by gain-of-function mutations in STING1 encoding stimulator of interferon genes …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling
pathway serves as a pivotal mediator of innate immunity by triggering the secretion of type I …

The cGAS-STING signaling plays an integral role in the host immune response, and the
abnormal activation of cGAS-STING is highly related to various autoimmune diseases …

Nucleic acids represent a major class of pathogen and damage signatures, recognized by a
variety of host sensors to initiate signaling cascades and immune responses, such as …

One of the oldest mechanisms of immune defense against pathogens is through detection of
foreign DNA. Since human DNA is compartmentalized into the nucleus, its presence in the …

STING acts as a cytosolic nucleotide sensor to trigger host defense upon viral or bacterial
infection. While STING hyperactivation can exert anti-tumor effects by increasing T cell …

Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …