Importance Worldwide, 47 million people live with dementia and, by 2050, the number is
expected to increase to 131 million. Observations Dementia is an acquired loss of cognition …

Importance Cognitive decline is a common and feared aspect of aging. Mild cognitive
impairment (MCI) is defined as the symptomatic predementia stage on the continuum of …

Background The escalating use of prescribed drugs has increasingly raised concerns about
polypharmacy. This study aims to examine changes in rates of polypharmacy and potentially …

Aims The aim of this study was to identify what definitions have been published for the term
'deprescribing', and determine whether a unifying definition could be reached. A secondary …

Multimorbidity, commonly defined as the presence of two or more chronic medical conditions
in an individual, 1 is associated with decreased quality of life, functional decline, and …

Introduction: Polypharmacy, defined as the use of multiple drugs or more than are medically
necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were …

Purpose The aim of the study was to develop a European list of potentially inappropriate
medications (PIM) for older people, which can be used for the analysis and comparison of …

In older patients, acute medical illness that requires hospitalization is a sentinel event that
often precipitates disability. This results in the subsequent inability to live independently and …

Globally, the number of drug prescriptions is increasing causing more adverse drug events,
which is now a significant cause of mortality, morbidity, and disability that has reached …

ANALYSIS Page 1 Adapting clinical guidelines to take account of multimorbidity Care of patients
with multimorbidity could be improved if new technology is used to bring together guidelines …