Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …

Because psychoactive plants exert profound effects on human perception, emotion, and
cognition, discovering the molecular mechanisms responsible for psychoactive plant actions …

Of great interest in recent years has been computationally predicting the novel
polypharmacology of drug molecules. Here, we applied an “induced-fit” protocol to improve …

Salvinorin A is a naturally occurring hallucinogenic diterpenoid from the plant Salvia
divinorum that selectively and potently activates κ-opioid receptors (KORs). Salvinorin A is …

Serotonin (5-hydroxytriptamine or 5-HT) is known to be a weak platelet agonist, and is
involved in thrombus formation. While 5-HT cannot induce platelet aggregation on its own …

A series of 10 thiourea derivatives have been synthesized by the reaction of aromatic amine
with a substituted aryl (compounds 1–3, 6–8) and alkylphenyl (4, 5, 9, 10) isothiocyanates …

Agonist activation of central 5‐HT2A receptors results in diverse effects, such as
hallucinations and changes of consciousness. Recent findings indicate that activation of the …

The effects of 3-position substitution of 9-aminomethyl-9, 10-dihydroanthracene (AMDA) on
5-HT2A receptor affinity were determined and compared to a parallel series of DOB-like 1 …

An overview of pharmacophore models, developed for different subtypes of serotonin
receptors belonging to the GPCR family, is presented. Starting with early models for 5-HT1A …

G-protein coupled receptors encoded by viruses represent an unexplored class of potential
drug targets. In this study, we describe the synthesis and pharmacological characterization …