How cancer hijacks the body's homeostasis through the neuroendocrine system

RM Slominski, C Raman, JY Chen, AT Slominski - Trends in neurosciences, 2023 - cell.com
During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …

Skin senescence: mechanisms and impact on whole-body aging

AC Franco, C Aveleira, C Cavadas - Trends in molecular medicine, 2022 - cell.com
The skin is the largest organ and has a key protective role. Similar to any other tissue, the
skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging …

Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides

AT Slominski, RM Slominski… - … of Physiology-Cell …, 2022 - journals.physiology.org
The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …

[HTML][HTML] Protective role of melatonin and its metabolites in skin aging

G Bocheva, RM Slominski, Z Janjetovic, TK Kim… - International journal of …, 2022 - mdpi.com
The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

How UV light touches the brain and endocrine system through skin, and why

AT Slominski, MA Zmijewski, PM Plonka… - …, 2018 - academic.oup.com
The skin, a self-regulating protective barrier organ, is empowered with sensory and
computing capabilities to counteract the environmental stressors to maintain and restore …

Roles of β-endorphin in stress, behavior, neuroinflammation, and brain energy metabolism

A Pilozzi, C Carro, X Huang - International journal of molecular sciences, 2020 - mdpi.com
β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced
through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist …

[HTML][HTML] The use of hair cortisol for the assessment of stress in animals

S Heimbürge, E Kanitz, W Otten - General and Comparative Endocrinology, 2019 - Elsevier
The hair cortisol concentration (HCC) is assumed to be a retrospective marker of integrated
cortisol secretion and stress over longer periods of time. Its quantification is increasingly …

UV radiation and the skin

J D'Orazio, S Jarrett, A Amaro-Ortiz, T Scott - International journal of …, 2013 - mdpi.com
UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and
a non-specific damaging agent and has properties of both a tumor initiator and a tumor …

The impact of vitamin D on skin aging

G Bocheva, RM Slominski, AT Slominski - International Journal of …, 2021 - mdpi.com
The active metabolites of vitamin D3 (D3) and lumisterol (L3) exert a variety of antiaging and
photoprotective effects on the skin. These are achieved through immunomodulation and …

Stress-induced interaction of skin immune cells, hormones, and neurotransmitters

N Pondeljak, L Lugović-Mihić - Clinical therapeutics, 2020 - Elsevier
Purpose Although scientific articles mention the impact of psychological stress on skin
diseases, few review the latest research on factors involved in this correlation. The skin …