Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease
in industrialized countries. NAFLD progresses through the inflammatory phase of non …

Background & Aims Endothelial dysfunction plays an essential role in liver injury, yet the
phenotypic regulation of liver sinusoidal endothelial cells (LSECs) remains unknown …

LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

The socioeconomic and medical improvements of the last decades have led to a relevant
increase in the median age of worldwide population. Although numerous studies described …

Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of
immune inflammatory responses and metabolic responses. Understanding the molecular …

Ischaemia/reperfusion injury is an important cause of liver damage during surgical
procedures such as hepatic resection and liver transplantation, and represents the main …

Cardiovascular disorders or cardiovascular diseases (CVD) are major illness associated
with heart and blood vessels. Reactive oxygen species (ROS), generated during excessive …

Abstract Reactive Oxygen Species (ROS) are key mediators of ischemia-reperfusion injury
but also required for the induction of the stress response that limits tissue injury and …

In cirrhosis, liver microvascular dysfunction is a key factor increasing hepatic vascular
resistance to portal blood flow, which leads to portal hypertension. De‐regulated …