Role of liver sinusoidal endothelial cells in liver diseases
J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …
other capillaries, they lack an organized basement membrane and have cytoplasm that is …
[HTML][HTML] Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic …
A Borrelli, P Bonelli, FM Tuccillo, ID Goldfine, JL Evans… - Redox biology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease
in industrialized countries. NAFLD progresses through the inflammatory phase of non …
in industrialized countries. NAFLD progresses through the inflammatory phase of non …
Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury
M Ruart, L Chavarria, G Campreciós… - Journal of …, 2019 - Elsevier
Background & Aims Endothelial dysfunction plays an essential role in liver injury, yet the
phenotypic regulation of liver sinusoidal endothelial cells (LSECs) remains unknown …
phenotypic regulation of liver sinusoidal endothelial cells (LSECs) remains unknown …
The evolving role of liver sinusoidal endothelial cells in liver health and disease
MJ McConnell, E Kostallari, SH Ibrahim, Y Iwakiri - Hepatology, 2023 - journals.lww.com
LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …
Effects of aging on liver microcirculatory function and sinusoidal phenotype
R Maeso‐Díaz, M Ortega‐Ribera… - Aging cell, 2018 - Wiley Online Library
The socioeconomic and medical improvements of the last decades have led to a relevant
increase in the median age of worldwide population. Although numerous studies described …
increase in the median age of worldwide population. Although numerous studies described …
[HTML][HTML] Targeting the hepatic microenvironment to improve ischemia/reperfusion injury: new insights into the immune and metabolic compartments
F Gao, X Qiu, K Wang, C Shao, W Jin, Z Zhang… - Aging and …, 2022 - ncbi.nlm.nih.gov
Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of
immune inflammatory responses and metabolic responses. Understanding the molecular …
immune inflammatory responses and metabolic responses. Understanding the molecular …
Molecular pathways in protecting the liver from ischaemia/reperfusion injury: a 2015 update
J Gracia-Sancho, A Casillas-Ramirez… - Clinical Science, 2015 - portlandpress.com
Ischaemia/reperfusion injury is an important cause of liver damage during surgical
procedures such as hepatic resection and liver transplantation, and represents the main …
procedures such as hepatic resection and liver transplantation, and represents the main …
Role of antioxidants for the treatment of cardiovascular diseases: challenges and opportunities
Cardiovascular disorders or cardiovascular diseases (CVD) are major illness associated
with heart and blood vessels. Reactive oxygen species (ROS), generated during excessive …
with heart and blood vessels. Reactive oxygen species (ROS), generated during excessive …
[HTML][HTML] ROS homeostasis, a key determinant in liver ischemic-preconditioning
I Prieto, M Monsalve - Redox biology, 2017 - Elsevier
Abstract Reactive Oxygen Species (ROS) are key mediators of ischemia-reperfusion injury
but also required for the induction of the stress response that limits tissue injury and …
but also required for the induction of the stress response that limits tissue injury and …
[PDF][PDF] Emricasan ameliorates portal hypertension and liver fibrosis in cirrhotic rats through a hepatocyte‐mediated paracrine mechanism
J Gracia‐Sancho, N Manicardi… - Hepatology …, 2019 - Wiley Online Library
In cirrhosis, liver microvascular dysfunction is a key factor increasing hepatic vascular
resistance to portal blood flow, which leads to portal hypertension. De‐regulated …
resistance to portal blood flow, which leads to portal hypertension. De‐regulated …