Mitochondria play a key role in maintaining cellular metabolic homeostasis. These
organelles have a high plasticity and are involved in dynamic processes such as …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

The mitochondria are involved in active and dynamic processes, such as mitochondrial
biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In …

High plasma levels of fatty acids occur in a variety of metabolic diseases. Cellular effects of
fatty acid overload resulting in negative cellular responses (lipotoxicity) are often studied in …

Abstract Changes in mitochondrial size and shape have been implicated in several
physiologic processes, but their role in mitochondrial Ca 2+ uptake regulation and overall …

Paraphrasing the Swiss physician and father of toxicology Paracelsus (1493–1541) on
chemical agents used as therapeutics,“the dose makes the poison,” it is now realized that …

Obesity has reached epidemic proportions and its prevalence is climbing. Obesity is
characterized by hypertrophied adipocytes with a dysregulated adipokine secretion profile …

Background Skeletal muscle stem cells (satellite cells) are well known to participate in
regeneration and maintenance of the tissue over time. Studies have shown increases in the …

Background: Diabetic nephropathy (DN) is an important diabetic microvascular
complication, and it is becoming the leading cause of end-stage renal disease worldwide …

Obesity significantly decreases life expectancy and increases the incidence of age‐related
dysfunctions, including β‐cell dysregulation leading to inadequate insulin secretion. Here …