[HTML][HTML] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

U Anand, A Dey, AKS Chandel, R Sanyal, A Mishra… - Genes & …, 2023 - Elsevier
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer

X Kong, Y Qi, X Wang, R Jiang, J Wang, Y Fang… - Progress in Materials …, 2023 - Elsevier
The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively
affected by the formation of tumor cell resistant clone and the severe toxicity of …

Polymeric nanoparticles: Promising platform for drug delivery

M Khalid, HS El-Sawy - International journal of pharmaceutics, 2017 - Elsevier
Nano medicine had viewed countless breakthroughs in drug delivery implementations. The
main objective of nanotechnology application in delivering and carrying many promising …

Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

AC Marques, PJ Costa, S Velho, MH Amaral - Journal of controlled release, 2020 - Elsevier
Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

MOF-based nanocomposites as transduction matrices for optical and electrochemical sensing

I Nandi, SK Rai, P Chandra - Talanta, 2024 - Elsevier
Abstract Metal Organic Frameworks (MOFs), a class of crystalline microporous materials
have been into research limelight lately due to their commendable physio-chemical …

Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells

CS Kumar, R Thangam, SA Mary, PR Kannan… - Carbohydrate …, 2020 - Elsevier
The present study is aimed to study and to evaluate the colon cancer targeting efficacy of
chitosan-coated-trans-resveratrol (RSV) and ferulic acid (FER) loaded SLNs (solid lipid …

Nanoparticles and DNA–a powerful and growing functional combination in bionanotechnology

A Samanta, IL Medintz - Nanoscale, 2016 - pubs.rsc.org
Functionally integrating DNA and other nucleic acids with nanoparticles in all their different
physicochemical forms has produced a rich variety of composite nanomaterials which, in …

Mechanisms of action of therapeutic antibodies for cancer

JM Redman, EM Hill, D AlDeghaither, LM Weiner - Molecular immunology, 2015 - Elsevier
The therapeutic utility of antibodies and their derivatives is achieved by various means. The
FDA has approved several targeted antibodies that disrupt signaling of various growth factor …

An overview of antibody conjugated polymeric nanoparticles for breast cancer therapy

A Juan, FJ Cimas, I Bravo, A Pandiella, A Ocaña… - Pharmaceutics, 2020 - mdpi.com
Nanoparticles (NPs) are promising drug delivery systems (DDS) for identifying and treating
cancer. Active targeting NPs can be generated by conjugation with ligands that bind …

Bimetallic ZrHf-based metal-organic framework embedded with carbon dots: Ultra-sensitive platform for early diagnosis of HER2 and HER2-overexpressed living …

C Gu, C Guo, Z Li, M Wang, N Zhou, L He… - Biosensors and …, 2019 - Elsevier
We report here a new bimetallic ZrHf metal–organic framework (ZrHf-MOF) embedded with
abundant carbon dots (CDs)(denoted as CDs@ ZrHf-MOF), which exhibits strong …