Detection and monitoring of virus infections by real-time PCR

F Watzinger, K Ebner, T Lion - Molecular aspects of medicine, 2006 - Elsevier
The employment of polymerase chain reaction (PCR) techniques for virus detection and
quantification offers the advantages of high sensitivity and reproducibility, combined with an …

HIV and hepatitis C virus co-infection

JK Rockstroh, U Spengler - The Lancet infectious diseases, 2004 - thelancet.com
Since the decline in HIV-related morbidity and mortality after introduction of highly active
antiretroviral therapy (HAART) in 1996, liver disease caused by chronic infection with …

[PDF][PDF] Persistence of hepatitis C virus in patients successfully treated for chronic hepatitis C

M Radkowski, JF Gallegos‐Orozco, J Jablonska… - …, 2005 - Wiley Online Library
It is unclear whether the current antiviral treatment for chronic hepatitis C virus (HCV)
infection results in complete elimination of the virus, or whether small quantities of virus …

Hepatitis C virus neuroinvasion: identification of infected cells

J Wilkinson, M Radkowski, T Laskus - Journal of virology, 2009 - Am Soc Microbiol
Hepatitis C virus (HCV) infection often is associated with cognitive dysfunction and
depression. HCV sequences and replicative forms were detected in autopsy brain tissue …

[PDF][PDF] Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences

JT Blackard, N Kemmer, KE Sherman - Hepatology, 2006 - Wiley Online Library
An estimated 170 million persons are infected with the hepatitis C virus (HCV) worldwide.
While hepatocytes are the major site of infection, a broad clinical spectrum of extrahepatic …

Cognitive dysfunction in chronic hepatitis C: a review

W Perry, RC Hilsabeck, TI Hassanein - Digestive diseases and sciences, 2008 - Springer
The hepatitis C virus (HCV) is a common blood-borne illness that affects up to 2% of the
world's population and almost 4 million Americans. Cognitive impairment, or difficulty with …

Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism

S Pal, DG Sullivan, S Kim, KKY Lai, J Kae, SJ Cotler… - Gastroenterology, 2006 - Elsevier
Background & Aims: The pathogenesis of chronic hepatitis C is poorly understood. This
study examines the ability of hepatitis C virus (HCV) to infect, replicate in, and produce …

Emerging evidence of hepatitis C virus neuroinvasion

T Laskus, M Radkowski, DM Adair, J Wilkinson… - Aids, 2005 - journals.lww.com
It has been reported that hepatitis C virus (HCV) infection is associated with cognitive
dysfunction, fatigue and depression, which do not correlate with the severity of liver disease …

Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV

S Letendre, AD Paulino, E Rockenstein… - The Journal of …, 2007 - academic.oup.com
Involvement of the nervous system by human immunodeficiency virus (HIV) continues to be
a serious problem. Among individuals with HIV who have a history of illicit drug use, those …

Activation of brain macrophages/microglia cells in hepatitis C infection

J Wilkinson, M Radkowski, JM Eschbacher, T Laskus - Gut, 2010 - gut.bmj.com
Objectives Hepatitis C virus (HCV) infection is commonly associated with cognitive
dysfunction. Viral sequences and proteins were previously found in brain …