Escherichia coli includes clonal groups of both commensal and pathogenic strains, with
some of the latter causing serious infectious diseases. O antigen variation is current …

Lipopolysaccharides are critical components of bacterial outer membranes. The more
conserved lipid A part of the lipopolysaccharide molecule is a major element in the …

Klebsiella pneumoniae is considered an urgent health concern due to the emergence of
multi-drug-resistant strains for which vaccination offers a potential remedy. Vaccines based …

Bacterial lipopolysaccharides are the major components of the outer surface of Gram-
negative bacteria They are often of interest in medicine for their immunomodulatory …

Pseudomonas aeruginosa causes serious nosocomial infections, and an important
virulence factor produced by this organism is lipopolysaccharide (LPS). This review …

Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

Carbapenemase and extended β-lactamase-producing Klebsiella pneumoniae isolates
represent a major health threat, stimulating increasing interest in immunotherapeutic …

Genomic approaches continue to provide unprecedented insight into the microbiome, yet
host immune interactions with diverse microbiota can be difficult to study. We therefore …

Humoral immune responses to microbial polysaccharide surface antigens can prevent
bacterial infection but are typically strain specific and fail to mediate broad protection against …

Klebsiella pneumoniae (Kp) is an opportunistic pathogen and the leading cause of
healthcare-associated infections, mostly affecting subjects with compromised immune …