[HTML][HTML] An overview on cardioprotective and anti-diabetic effects of thymoquinone

T Farkhondeh, S Samarghandian, A Borji - Asian Pacific journal of tropical …, 2017 - Elsevier
Thymoquinone (TQ), one of the active components of Nigella sativa exhibited to have many
biological effects. Several beneficial effects of TQ such as its antidiabetic, antioxidant …

Euphorbia helioscopia L.: A phytochemical and pharmacological overview

Y Yang, X Chen, F Luan, M Wang, Z Wang, J Wang… - Phytochemistry, 2021 - Elsevier
Highlights•The medicinal uses, phytochemistry, pharmacology, toxicology and clinical
application of E. helioscopia are summarized.•Terpenoids are the major chemical …

β-Carotene: a natural compound improves cognitive impairment and oxidative stress in a mouse model of streptozotocin-induced Alzheimer's disease

S Hira, U Saleem, F Anwar, MF Sohail, Z Raza… - Biomolecules, 2019 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a cascade of
changes in cognitive, behavioral, and social activities. Several areas of the brain are …

Exploring the therapeutic potentials of highly selective oxygenated chalcone based MAO-B inhibitors in a haloperidol-induced murine model of Parkinson's disease

DGT Parambi, U Saleem, MA Shah, F Anwar… - Neurochemical …, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder of dopaminergic, noradrenergic,
and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are …

In silico study and pharmacological evaluation of Eplerinone as an Anti-Alzheimer's drug in STZ-induced Alzheimer's disease model

S Hira, U Saleem, F Anwar, Z Raza, AU Rehman… - ACS …, 2020 - ACS Publications
Alzheimer's disease (AD) is the neurodegenerative disorder characterized by impairment of
higher intellectual dysfunctions associated with changes in the cognitive, behavioral, and …

Parkinsonism attenuation by antihistamines via downregulating the oxidative stress, histamine, and inflammation

M Ayaz, F Anwar, U Saleem, I Shahzadi, B Ahmad… - ACS …, 2022 - ACS Publications
Parkinson disease (PD) is a neurodegenerative disorder of the motor activity of the brain,
regulated by dopaminergic neurons of substantia nigra, resulting in an increased density of …

Antioxidants attenuate isolation-and L-DOPA-induced aggression in mice

S Hira, U Saleem, F Anwar, B Ahmad - Frontiers in pharmacology, 2018 - frontiersin.org
Aggression is a major hallmark worldwide attributing negative traits in personality. Wide
variety of antioxidants is used for the treatment of many ailments. The present study was …

Attenuation of carbohydrate metabolism and lipid profile by methanolic extract of Euphorbia helioscopia and improvement of beta cell function in a type 2 diabetic rat …

I Mustafa, H Anwar, S Irfan, H Muzaffar… - … Medicine and Therapies, 2022 - Springer
Background Traditional plant-based remedies prescribed to treat diabetes have shown
promise in research-based setting. Current research was conducted to examine the …

Diterpenoids from Euphorbia helioscopia and their enhancement of NK cell-mediated killing of NSCLC cells

H Mu, C Gong, R Zhang, Z Chen, S Zhu, W Zhao - Bioorganic Chemistry, 2022 - Elsevier
Fourteen previously undescribed diterpenoids, including an unusual diterpenoid (1) with a
9, 10-seco-jatrophane skeleton, ten jatrophane-type diterpenoids (2–11), two lathyrane-type …

Systems pharmacology based approach to investigate the in-vivo therapeutic efficacy of Albizia lebbeck (L.) in experimental model of Parkinson's disease

U Saleem, Z Raza, F Anwar, Z Chaudary… - … and Alternative Medicine, 2019 - Springer
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
characterized by loss of dopaminergic neurons in substantia nigra pars compacta and …