Genetic information is translated into proteins by the ribosome. Structural studies of the
ribosome and of its complexes with factors and inhibitors have provided invaluable …

The ribosome is one of the major targets in the cell for clinically used antibiotics. However,
the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our …

Chemical modifications of RNAs have long been established as key modulators of
nonprotein-coding RNA structure and function in cells. There is a growing appreciation that …

Natural products serve as chemical blueprints for most antibiotics in clinical use. The
evolutionary process by which these molecules arise is inherently accompanied by the co …

The ever-growing rise of antibiotic resistance among bacterial pathogens is one of the top
healthcare threats today. Although combination antibiotic therapies represent a potential …

The ribosome exit tunnel is an important structure involved in the regulation of translation
and other essential functions such as protein folding. By comparing 20 recently obtained …

The bacterial ribosome is an essential drug target as many clinically important antibiotics
bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is …

The 70S ribosome is a major target for antibacterial drugs. Two of the classical antibiotics,
chloramphenicol (CHL) and erythromycin (ERY), competitively bind to adjacent but separate …

Ribosome-synthesized post-translationally modified peptides (RiPPs) represent a rapidly
expanding class of natural products with various biological activities. Linear azol (in) e …

Many pharmaceutical companies are avoiding the development of novel antibacterials due
to a range of rational reasons and the high risk of failure. However, there is an urgent need …