Craniopharyngiomas are rare, partly cystic and calcified embryonic malformations of the
sellar/parasellar region with low histological grade (WHO Io). A bimodal age distribution has …

Craniopharyngiomas (CPs) are clinically aggressive tumors because of their invasive
behavior and recalcitrant tendency to recur after therapy. There are 2 types based on their …

Abstract We developed Lisa (http://lisa. cistrome. org/) to predict the transcriptional
regulators (TRs) of differentially expressed or co-expressed gene sets. Based on the input …

The anterior pituitary gland plays a central role in regulating various physiological
processes, including body growth, reproduction, metabolism and stress response. Here, we …

Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer,
fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular …

Transcription factors and signaling pathways that regulate stem cells and specialized
hormone-producing cells in the pituitary gland have been the subject of intense study and …

Despite their importance in tissue homeostasis and renewal, human pituitary stem cells
(PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and …

Adamantinomatous craniopharyngiomas (ACPs) are clinically challenging tumours, the
majority of which have activating mutations in CTNNB1. They are histologically complex …

Extracellular vesicles (EVs) are known mediators of intercellular communication for both
normal and tumour cells. With the capability to transfer nucleic acids, proteins and lipids …

Childhood-onset craniopharyngiomas are rare embryonic tumours of low-grade histological
malignancy. Novel insights into the molecular pathogenesis of human adamantinomatous …