Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and
regeneration. This requires significant proliferative potential ensured by sufficient telomere …

The cornea is the outermost layer of the eye and plays an essential role in our visual system.
Limbal epithelial stem cells (LESCs), which are localized to a highly regulated limbal niche …

Organ culture storage techniques for corneoscleral limbal (CSL) tissue have improved the
quality of corneas for transplantation and allow for longer storage times. Cultured limbal …

Limbal epithelial stem/progenitor cells (LSCs) reside in a niche that contains finely tuned
balances of various signaling pathways including Wnt, Notch, BMP, Shh, YAP, and TGFβ …

The transplantation of ex vivo expanded limbal epithelial progenitor cells (LEPCs) on
amniotic membrane or fibrin gel is an established therapeutic strategy to regenerate the …

Interactions between limbal epithelial progenitor cells (LEPC) and surrounding niche cells,
which include limbal mesenchymal stromal cells (LMSC) and melanocytes (LM), are …

Haematopoietic stem cells are the basis for building and maintaining lifelong
haematopoietic mechanisms and an important resource for the treatment of blood disorders …

Epidermolysis bullosa (EB) is a rare genetic dermatosis characterized by skin fragility and
blister formation. With a wide phenotypic spectrum and potential extracutaneous …

The cornea is an ideal testing field for cell therapies. Its highly ordered structure, where
specific cell populations are sequestered in different layers, together with its accessibility …