Functional roles of pulsing in genetic circuits
A fundamental problem in biology is to understand how genetic circuits implement core
cellular functions. Time-lapse microscopy techniques are beginning to provide a direct view …
cellular functions. Time-lapse microscopy techniques are beginning to provide a direct view …
Microbial individuality: how single-cell heterogeneity enables population level strategies
BMC Martins, JCW Locke - Current opinion in microbiology, 2015 - Elsevier
Highlights•Gene expression can be surprisingly dynamic and noisy.•Cell to cell
heterogeneity in gene expression state is a widespread phenomenon.•Phenotypic diversity …
heterogeneity in gene expression state is a widespread phenomenon.•Phenotypic diversity …
Cell-to-cell variation in p53 dynamics leads to fractional killing
Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We
used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon …
used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon …
Coordination of bacterial proteome with metabolism by cyclic AMP signalling
The cyclic AMP (cAMP)-dependent catabolite repression effect in Escherichia coli is among
the most intensely studied regulatory processes in biology. However, the physiological …
the most intensely studied regulatory processes in biology. However, the physiological …
Response mechanisms of different antibiotic-resistant bacteria with different resistance action targets to the stress from photocatalytic oxidation
Y Liu, Y Cai, G Li, W Wang, PK Wong, T An - Water Research, 2022 - Elsevier
The stress response of antibiotic-resistant bacteria (ARB) and the spread of antibiotic
resistance genes (ARGs) pose a serious threat to the aquatic environment and human …
resistance genes (ARGs) pose a serious threat to the aquatic environment and human …
Carbon content and climate variability drive global soil bacterial diversity patterns
M Delgado‐Baquerizo, FT Maestre… - Ecological …, 2016 - Wiley Online Library
Despite the vital role of microorganisms for ecosystem functioning and human welfare, our
understanding of their global diversity and biogeographical patterns lags significantly …
understanding of their global diversity and biogeographical patterns lags significantly …
Characterizing bacterial gene circuit dynamics with optically programmed gene expression signals
Gene circuits are dynamical systems that regulate cellular behaviors, often using protein
signals as inputs and outputs. Here we have developed an optogenetic'function …
signals as inputs and outputs. Here we have developed an optogenetic'function …
Meta‐analysis of the coral environmental stress response: Acropora corals show opposing responses depending on stress intensity
As climate change progresses, reef‐building corals must contend more often with
suboptimal conditions, motivating a need to understand coral stress response. Here, we test …
suboptimal conditions, motivating a need to understand coral stress response. Here, we test …
Programming bacteria with light—sensors and applications in synthetic biology
Z Liu, J Zhang, J Jin, Z Geng, Q Qi, Q Liang - Frontiers in microbiology, 2018 - frontiersin.org
Photo-receptors are widely present in both prokaryotic and eukaryotic cells, which serves as
the foundation of tuning cell behaviors with light. While practices in eukaryotic cells have …
the foundation of tuning cell behaviors with light. While practices in eukaryotic cells have …
Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells
I Heemskerk, K Burt, M Miller, S Chhabra, MC Guerra… - Elife, 2019 - elifesciences.org
During embryonic development, diffusible signaling molecules called morphogens are
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …