Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles

E Trampari, F Prischi, AV Vargiu, J Abi-Assaf… - npj Antimicrobials and …, 2023 - nature.com
Antibiotic resistance is a pressing healthcare challenge and is mediated by various
mechanisms, including the active export of drugs via multidrug efflux systems, which prevent …

Cobalt complexes modulate plasmid conjugation in Escherichia coli and Klebsiella pneumoniae

I Alav, P Pordelkhaki, PE de Resende, H Partington… - Scientific Reports, 2024 - nature.com
Antimicrobial resistance genes (ARG), such as extended-spectrum β-lactamase (ESBL) and
carbapenemase genes, are commonly carried on plasmids. Plasmids can transmit between …

Identification of pathways required for Salmonella to colonize alfalfa using TraDIS-Xpress

ER Holden, J Abi Assaf, H Al-Khanaq… - Applied and …, 2024 - Am Soc Microbiol
Enteropathogenic bacteria, such as Salmonella, have been linked to numerous fresh
produce outbreaks, posing a significant public health threat. The ability of Salmonella to …

Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella

E Trampari, C Zhang, K Gotts, GM Savva… - Microbiology …, 2022 - Am Soc Microbiol
Cephalosporins are important beta lactam antibiotics, but resistance can be mediated by
various mechanisms including production of beta lactamase enzymes, changes in …

Metal complexes and conjugation: Harnessing the power of cobalt complexes to curtail plasmid transfer

I Alav, P Pordelkhaki, PE de Resende, H Partington… - bioRxiv, 2023 - biorxiv.org
Background: Antimicrobial resistance genes (ARG), such as extended spectrum beta-
lactamase (ESBL) and carbapenemase genes, are commonly carried on plasmids. Plasmids …

Reversible excision of the wzy locus in Salmonella Typhimurium may aid recovery following phage predation

OJD Charity, G Thilliez, H Al-Khanaq, L Acton… - bioRxiv, 2024 - biorxiv.org
Bacteriophage (phage) are promising novel antimicrobials but a key challenge to their
effective implementation is the rapid emergence of phage resistance. An improved …

Comparison of the genetic basis of biofilm formation between Salmonella Typhimurium and Escherichia coli

ER Holden, M Yasir, AK Turner… - Microbial …, 2022 - microbiologyresearch.org
Most bacteria can form biofilms, which typically have a life cycle from cells initially attaching
to a surface before aggregation and growth produces biomass and an extracellular matrix …

Investigating how Salmonella colonise alfalfa using a whole genome screen

ER Holden, H Al-Khanaq, N Vimont, MA Webber… - bioRxiv, 2023 - biorxiv.org
Enteropathogenic bacteria including Salmonella regularly cause outbreaks of infection from
fresh produce posing a significant public health threat. Salmonella's ability to persist on fresh …

Oligonucleotide Library Assisted Sequence Mining Reveals Promoter Sequences With Distinct Temporal Expression Dynamics For Applications In Curvibacter SP …

M Mager, L Becker, N Schulten, S Fraune, IM Axmann - bioRxiv, 2024 - biorxiv.org
The β-proteobacterial species Curvibacter sp. AEP1-3 is a model organism for the study of
symbiotic interactions as it is the most abundant bacterial colonizer of the basal metazoan …

Massively parallel transposon mutagenesis to identify relationships between biofilm formation and efflux activity in Enterobacteriaceae

E Holden - 2021 - ueaeprints.uea.ac.uk
Bacteria are usually found as part of structured, aggregated communities called biofilms.
Progression through the biofilm life cycle requires temporally controlled gene expression to …