Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's. PD is considered a multifactorial disorder that results, in most cases, from the …

Background Prognosis in Parkinson's disease (PD) remains poorly understood due to a lack
of unbiased data on the natural history of treated PD. The CamPaIGN study has been the …

The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

Background People with dementia die prematurely. Identifying differences in mortality rates
between different types of dementia might aid in the development of preventive interventions …

Methods We used Canadian and American national guidelines to inform this review, in
addition to published systematic reviews that were known to us. We identified additional …

Parkinson's disease (PD) affects 1–2 per 1000 of the population at any time. PD prevalence
is increasing with age and PD affects 1% of the population above 60 years. The main …

Cognitive impairment in patients with Parkinson's disease is gaining increased clinical
significance owing to the relative success of therapeutic approaches to the motor symptoms …

The causes of Parkinson's disease (PD), the second most common neurodegenerative
disorder, are still largely unknown. Current thinking is that major gene mutations cause only …

Dementia has been increasingly more recognized to be a common feature in patients with
Parkinson's disease (PD), especially in old age. Specific criteria for the clinical diagnosis of …