Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations
DJ Hausenloy, HE Botker, T Engstrom… - European heart …, 2017 - academic.oup.com
Ischaemic heart disease (IHD) remains the leading cause of death and disability in Europe
and worldwide. A major cause of morbidity and mortality in IHD patients is an acute ST …
and worldwide. A major cause of morbidity and mortality in IHD patients is an acute ST …
Myocardial reperfusion injury
DM Yellon, DJ Hausenloy - New England Journal of Medicine, 2007 - Mass Medical Soc
Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration
of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of …
of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of …
Temperature monitoring and perioperative thermoregulation
DI Sessler, DS Warner, MA Warner - The Journal of the American …, 2008 - pubs.asahq.org
Most clinically available thermometers accurately report the temperature of whatever tissue
is being measured. The difficulty is that no reliably core-temperature-measuring sites are …
is being measured. The difficulty is that no reliably core-temperature-measuring sites are …
Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods
KH Polderman, I Herold - Critical care medicine, 2009 - journals.lww.com
Background: Hypothermia is being used with increasing frequency to prevent or mitigate
various types of neurologic injury. In addition, symptomatic fever control is becoming an …
various types of neurologic injury. In addition, symptomatic fever control is becoming an …
Induced hypothermia and fever control for prevention and treatment of neurological injuries
KH Polderman - The Lancet, 2008 - thelancet.com
Increasing evidence suggests that induction of mild hypothermia (32–35° C) in the first hours
after an ischaemic event can prevent or mitigate permanent injuries. This effect has been …
after an ischaemic event can prevent or mitigate permanent injuries. This effect has been …
Post cardiac arrest syndrome: a review of therapeutic strategies
Out-of-hospital cardiac arrest (OHCA) is a common initial presentation of cardiovascular
disease, affecting up to 325 000 people in the United States each year. 1 In a recent meta …
disease, affecting up to 325 000 people in the United States each year. 1 In a recent meta …
Rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial …
Objectives: The aim of this study was to confirm the cardioprotective effects of hypothermia
using a combination of cold saline and endovascular cooling. Background: Hypothermia has …
using a combination of cold saline and endovascular cooling. Background: Hypothermia has …
[HTML][HTML] Application of therapeutic hypothermia in the intensive care unit: Opportunities and pitfalls of a promising treatment modality—Part 2: Practical aspects and …
KH Polderman - Intensive care medicine, 2004 - Springer
Induced hypothermia can be used to protect the brain from post-ischemic and traumatic
neurological injury. Potential clinical applications and the available evidence are discussed …
neurological injury. Potential clinical applications and the available evidence are discussed …
A pilot study of rapid cooling by cold saline and endovascular cooling before reperfusion in patients with ST-elevation myocardial infarction
M Götberg, GK Olivecrona, S Koul… - Circulation …, 2010 - Am Heart Assoc
Background—Experimental studies have shown that induction of hypothermia before
reperfusion of acute coronary occlusion reduces infarct size. Previous clinical studies …
reperfusion of acute coronary occlusion reduces infarct size. Previous clinical studies …
Therapeutic strategies for ischemia reperfusion injury in emergency medicine
H Naito, T Nojima, N Fujisaki… - Acute medicine & …, 2020 - Wiley Online Library
Ischemia reperfusion (IR) injury occurs when blood supply, perfusion, and concomitant
reoxygenation is restored to an organ or area following an initial poor blood supply after a …
reoxygenation is restored to an organ or area following an initial poor blood supply after a …