Transforming growth factor-β (TGFβ) family members are structurally and functionally related
cytokines that have diverse effects on the regulation of cell fate during embryonic …

FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

It is well established that tissue repair depends on stem cells and that chronic wounds
predispose to tumour formation. However, the association between stem cells, wound …

Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and
progression, since stromal elements are required to generate the optimal conditions for …

Background Tumor associated fibroblasts (TAF), are essential for tumor progression
providing both a functional and structural supportive environment. TAF, known as activated …

Reactive stroma initiates during early prostate cancer development and coevolves with
prostate cancer progression. Previous studies have defined the key markers of reactive …

Biological processes that drive cell growth are exciting targets for cancer therapy. The
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …

By comparing the expression profiles of microRNAs (miRNAs) in different hepatocellular
carcinoma (HCC) subtypes, we identified miR‐140‐5p as an HCC‐related miRNA. We …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Animal models, particularly mouse models, play a central role in the study of the etiology,
prevention, and treatment of human prostate cancer. While tissue culture models are …