JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Q Hu, Q Bian, D Rong, L Wang, J Song… - … in Bioengineering and …, 2023 - frontiersin.org
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …
originally thought to be intracellular signaling pathways that mediate cytokine signals in …
The unique structural and functional features of CXCL12
R Janssens, S Struyf, P Proost - Cellular & molecular immunology, 2018 - nature.com
The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …
The role of the CXCL12/CXCR4/ACKR3 axis in autoimmune diseases
EM García-Cuesta, CA Santiago… - Frontiers in …, 2019 - frontiersin.org
Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …
receptors are intimately involved in cell movement, and thus play a critical role in several …
The role of IL-6 and STAT3 in inflammation and cancer
DR Hodge, EM Hurt, WL Farrar - European journal of cancer, 2005 - Elsevier
The defense of the host from foreign pathogens is the commonly accepted function of the
vertebrate immune system. A complex system consisting of many differing cells and …
vertebrate immune system. A complex system consisting of many differing cells and …
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …
Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives
L Pawig, C Klasen, C Weber, J Bernhagen… - Frontiers in …, 2015 - frontiersin.org
CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …
and their recruitment to sites of injury, as well as affect processes such as cell arrest …
The redox protein high-mobility group box 1 in cell death and cancer
Significance: As a redox-sensitive protein, high-mobility group box 1 (HMGB1) is implicated
in regulating stress responses to oxidative damage and cell death, which are closely related …
in regulating stress responses to oxidative damage and cell death, which are closely related …
Bruton's tyrosine kinase and phospholipase Cγ2 mediate chemokine-controlled B cell migration and homing
DJJ de Gorter, EA Beuling, R Kersseboom… - Immunity, 2007 - cell.com
Control of integrin-mediated adhesion and migration by chemokines plays a critical role in B
cell development, differentiation, and function; however, the underlying signaling …
cell development, differentiation, and function; however, the underlying signaling …
Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology
M Li, RM Ransohoff - Progress in neurobiology, 2008 - Elsevier
Chemotactic cytokines (chemokines) have been traditionally defined as small (10–14kDa)
secreted leukocyte chemoattractants. However, chemokines and their cognate receptors are …
secreted leukocyte chemoattractants. However, chemokines and their cognate receptors are …