Nucleic acids modulate liquidity and dynamics of artificial membraneless organelles

J Liu, F Zhorabek, Y Chau - ACS Macro Letters, 2022 - ACS Publications
Liquid–liquid phase separation (LLPS) emerges as a fundamental underlying mechanism
for the biological organization, especially the formation of membraneless organelles (MLOs) …

Control of enzyme reactivity in response to osmotic pressure modulation mimicking dynamic assembly of intracellular organelles

C Schvartzman, H Zhao, E Ibarboure… - Advanced …, 2023 - Wiley Online Library
In response to variations in osmotic stress, in particular to hypertonicity associated with
biological dysregulations, cells have developed complex mechanisms to release their …

Constructing Phase Separation in Polymer Gels: Strategies, Functions and Applications

Z Wang, W Qiu, Q Zhang - Progress in Polymer Science, 2024 - Elsevier
Over the past decades, there has been a flourishing of phase-separated polymer gels.
Unlike traditional design methods that rely on chemical structure and polymer network …

Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis

S Cao, T Ivanov, J Heuer, CTJ Ferguson… - Nature …, 2024 - nature.com
Artificial organelles can manipulate cellular functions and introduce non-biological
processes into cells. Coacervate droplets have emerged as a close analog of …

Recent advances in design and application of synthetic membraneless organelles

L Wan, Y Zhu, W Zhang, W Mu - Biotechnology Advances, 2024 - Elsevier
Membraneless organelles (MLOs) formed by liquid-liquid phase separation (LLPS) have
been extensively studied due to their spatiotemporal control of biochemical and cellular …

Give crucibles to a prokaryote

J Liu, T Zhang, X Liu, BZ Tang - Matter, 2022 - cell.com
Prokaryotes are hodgepodge-like" bags" with minimal intracellular organization. Recently in
Angewandte Chemie International Edition, Xia et al. synthesized artificial membraneless …

Liquid capsules for gastrointestinal drug delivery

J Liu, SL Perry, BZ Tang, MV Tirrell - Matter, 2022 - cell.com
Recently, Margossian et al. reported pH-responsive complex coacervates formed by a
polyzwitterion and a polyelectrolyte in Nature Communications, which remain intact under …

From chemistry to dentistry: Paving my uncommon way to Harvard School of Dental Medicine as a materials scientist

J Liu - Matter, 2022 - cell.com
Being an underrepresented minority with a unique background in a research community can
be peculiar and double-edged. Here, Dr. Jianhui Liu, a new Post-doctoral Fellow at Harvard …

How art impacts my science

J Liu - Matter, 2022 - cell.com
How art impacts my science Page 1 Matter of Opinion How art impacts my science Jianhui
Liu1,2,3,4,* Art and science are never incompatible. In this Matter of Opinion, Dr. Jianhui Liu …

Modulation of heterotypic and homotypic interactions to visualize the evolution of organic aggregates in a fluorescence turn-on manner

C Xu, X Ou, B Wang, H Shen, J Liu… - Journal of the …, 2024 - ACS Publications
The abnormal evolution of membrane-less organelles into amyloid fibrils is a causative
factor in many neurodegenerative diseases. Fundamental research on evolving organic …