Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain
functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis …

Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout
the brain via widespread efferent projections, and plays a pivotal role in modulating …

Abstract 11C-BU99008 is a novel positron emission tomography (PET) tracer that enables
selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated …

Many neurodegenerative diseases are neuropathologically characterized by neuronal loss,
gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau …

Alzheimer's disease (AD) is characterized by memory loss and decline of cognitive function,
associated with progressive neurodegeneration. While neuropathological processes like …

With reactive astrogliosis being established as one of the hallmarks of Alzheimer's disease
(AD), there is high interest in developing novel positron emission tomography (PET) tracers …

Since Bousquet et al. discovered the imidazoline binding sites (IBS) two decades ago, when
they realized that the antihypertensive drug clonidine interacts not only with the α2 …

Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in
neurodegeneration in Alzheimer's disease. We explored this in vivo using multimodal PET …

Imidazoline binding sites (IBS) were proposed to be responsible for some of the
pharmacological and therapeutic activities of imidazoline and related compounds and have …