Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both
vertebrates and ticks, and efficient means of transmission between those two very different …

Background Biofilm development, specifically the fundamentally adaptive switch from acute
to chronic infection phenotypes, requires global regulators and small non-coding regulatory …

Highlights•We reveal the undiscovered regions of flagellar assembly that have been poorly
investigated so far.•Available structural information is systematically summarized.• …

Borrelia burgdorferi, the causative agent of Lyme disease, survives in nature through a cycle
that alternates between ticks and vertebrates. To facilitate this defined lifestyle, B. burgdorferi …

The bacterial stringent response is triggered by deficiencies of available nutrients and other
environmental stresses. It is mediated by 5'-triphosphate-guanosine-3'-diphosphate and 5' …

Regulation of translation is critical for maintaining cellular protein levels, and thus protein
homeostasis. The conserved RNA-binding protein CsrA (also called RsmA; for carbon …

CsrA (carbon storage regulator A) is a widely distributed bacterial RNA binding protein that
regulates translation initiation and mRNA stability of target transcripts. In γ-proteobacteria …

Borrelia burgdorferi responds to a variety of host-derived factors and appropriately alters its
gene expression for adaptation under different host-specific conditions. We previously …

The requirements for bacterial chemotaxis and motility range from dispensable to crucial for
host colonization. Even though more than 50% of all sequenced prokaryotic genomes …