The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …

There is an increasing amount of evidence that biomolecular condensates are linked to
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …

Parkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy
Bodies and Lewy Neurites containing α-synuclein fibrils. The underlying aggregation …

The progress toward understanding the molecular basis of Alzheimers's disease is strongly
connected to elucidating the early aggregation events of the amyloid-β (Aβ) peptide …

The amlyoid-β peptide (Aβ) is closely linked to the development of Alzheimer's disease.
Molecular dynamics (MD) simulations have become an indispensable tool for studying the …

α-Synuclein is a protein that is intrinsically disordered in vitro and prone to aggregation,
particularly at high temperatures. In this work, we examined the ability of curcumin, a …

The understanding of the complex conformational landscape of amyloid aggregation and its
modulation by relevant physicochemical and cellular factors is a prerequisite for elucidating …

Protein aggregation into highly structured amyloid fibrils is associated with various diseases
including Alzheimer's disease, Parkinson's disease, and type II diabetes. Amyloids can also …

The solvation shell is essential for the folding and function of proteins, but how it contributes
to protein misfolding and aggregation has still to be elucidated. We show that the mobility of …

Lysine-selective molecular tweezers (MTs) are supramolecular host molecules displaying a
remarkably broad spectrum of biologic activities. MTs act as inhibitors of the self-assembly …