This review summarizes reports of recurrent DNA sequence copy number amplifications in
human neoplasms detected by comparative genomic hybridization. Some of the …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer in large part due to late
diagnosis and a lack of effective screening tests. In spite of recent progress in imaging …

Purpose: Multiple chromosome abnormalities, including gain of chromosome20q, have
been detected frequently in human pancreatic cancers. Overexpression of the …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. To
identify biologically relevant genes with prognostic and therapeutic significance in PDAC …

KRAS mutated tumours represent a large fraction of human cancers, but the vast majority
remains refractory to current clinical therapies. Thus, a deeper understanding of the …

The pancreatic adenocarcinoma genome harbors multiple amplifications and deletions,
pointing to the existence of numerous oncogenes and tumor suppressor genes driving the …

Genetic changes involved in the development and progression of pancreatic cancer are still
partly unknown, despite the progress in recent years. In this study, comparative genomic …

Abstract AURKA/STK15/BTAK, the gene encoding Aurora A kinase that is involved in the
regulation of centrosomes and segregation of chromosomes, is frequently amplified and …

Purpose: The targeting protein for Xklp2 (TPX2) has recently gained attention as a putative
oncogene possibly amplified in several human malignancies, including pancreatic …

To screen pancreatic carcinomas for chromosomal aberrations we have applied molecular
cytogenetic techniques, including fluorescent in situ hybridization, comparative genomic …