Transcription and its regulation pose challenges related to DNA torsion and supercoiling of
the DNA template. RNA polymerase tracking the helical groove of the DNA introduces …

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons,,,–. Whether neurons …

The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids.
The knowledge about their respective interactions is as important as the individual …

Pausing of RNA polymerase II (Pol II) at transcription start sites (TSSs) primes target genes
for productive elongation. Coincidentally, DNA double-strand breaks (DSBs) enrich at highly …

Neurons in the brain are continuously exposed to various sources of DNA damage.
Although the mechanisms of DNA damage repair in mitotic cells have been extensively …

Emotional experiences often evoke neural plasticity that supports adaptive changes in
behavior, including maladaptive plasticity associated with mood and substance use …

DNA strand breaks excessively accumulate in the brains of patients with Alzheimer's
disease (AD). While traditionally considered random, deleterious events, neuron activity …

Bioelectricity plays a crucial role in organisms, being closely connected to neural activity and
physiological processes. Disruptions in the nervous system can lead to chaotic ionic …

Stimuli that stimulate neurons elicit transcription of immediate-early genes, a process which
requires local sites of chromosomal DNA to form double-strand breaks (DSBs) generated by …

Background: DNA breaks accumulate in Alzheimer's disease (AD) brains. While their role as
true genomic lesions is recognized, DNA breaks also support cognitive function by …