[HTML][HTML] Insulin-like growth factors: Ligands, binding proteins, and receptors
Background The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin),
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …
Children born small for gestational age: differential diagnosis, molecular genetic evaluation, and implications
MJJ Finken, M van der Steen, CCJ Smeets… - Endocrine …, 2018 - academic.oup.com
Children born small for gestational age (SGA), defined as a birth weight and/or length
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …
40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton
The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …
Disorders of IGFs and IGF-1R signaling pathways
BE Forbes, AJ Blyth, JM Wit - Molecular and cellular endocrinology, 2020 - Elsevier
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …
regulate multiple physiological processes, including mammalian development, metabolism …
IGF2: Development, Genetic and Epigenetic Abnormalities
C Sélénou, F Brioude, E Giabicani, ML Sobrier… - Cells, 2022 - mdpi.com
In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …
knockout mouse models, we have learnt much about the structure of this protein, its role and …
Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea
S Zhang, Y Zhang, Y Dong, L Guo, Z Zhang… - Cellular and molecular …, 2020 - Springer
Foxg1 is one of the forkhead box genes that are involved in morphogenesis, cell fate
determination, and proliferation, and Foxg1 was previously reported to be required for …
determination, and proliferation, and Foxg1 was previously reported to be required for …
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
Much of the mammalian skeleton originates from a cartilage template eventually replaced by
bone via endochondral ossification. Despite much knowledge about growth factors and …
bone via endochondral ossification. Despite much knowledge about growth factors and …
The actions of IGF-1 in the growth plate and its role in postnatal bone elongation
HL Racine, MA Serrat - Current osteoporosis reports, 2020 - Springer
Abstract Purpose of Review Bone elongation is a complex process driven by multiple
intrinsic (hormones, growth factors) and extrinsic (nutrition, environment) variables. Bones …
intrinsic (hormones, growth factors) and extrinsic (nutrition, environment) variables. Bones …
The emerging role of glucose metabolism in cartilage development
JM Hollander, L Zeng - Current osteoporosis reports, 2019 - Springer
Abstract Purpose of Review Proper cartilage development is critical to bone formation during
endochondral ossification. This review highlights the current understanding of various …
endochondral ossification. This review highlights the current understanding of various …
Deletion of Glut1 in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxidation
Glucose metabolism is fundamental for the functions of all tissues, including cartilage.
Despite the emerging evidence related to glucose metabolism in the regulation of prenatal …
Despite the emerging evidence related to glucose metabolism in the regulation of prenatal …