An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin

E Rosini, NA Volpi, B Ziffels, A Grimaldi… - … , Biology and Medicine, 2021 - Elsevier
In order to generate an antibody directed enzyme prodrug therapy, here we designed a
chimeric protein by fusing the F8 antibody that recognizes the EDA of fibronectin (expressed …

Optimized rapid production of recombinant secreted proteins in CHO cells grown in suspension: The case of RBD

E Rosini, L Pollegioni - Biotechnology and Applied …, 2023 - Wiley Online Library
Abstract Chinese Hamster Ovary cells (CHO) have become the most common workhorse for
the commercial production of therapeutic proteins, as well as for the production of …

[引用][C] HSV-IgM 人-鼠嵌合抗体制备及稳定细胞株构建工艺开发

崔亚敏, 田晓平, 孙静静, 王志强, 赵巧辉, 李桂林 - 生物工程学报, 2023