Metabotropic Regulation of RhoA/Rho-Associated Kinase by L-type Ca2+ Channels: New Mechanism for Depolarization-Evoked Mammalian Arterial Contraction
M Fernández-Tenorio, C Porras-González… - Circulation …, 2011 - Am Heart Assoc
Background: Sustained vascular smooth muscle contraction is mediated by extracellular
Ca2+ influx through L-type voltage-gated Ca2+ channels (VGCC) and RhoA/Rho …
Ca2+ influx through L-type voltage-gated Ca2+ channels (VGCC) and RhoA/Rho …
The role of ion channels in hypoxic pulmonary vasoconstriction
EK Weir, JA Cabrera, S Mahapatra… - … and Transporters in …, 2010 - Springer
Hypoxic pulmonary vasoconstriction (HPV) is an important mechanism by which localized
flow of blood in small resistance pulmonary arteries is matched to alveolar ventilation. This …
flow of blood in small resistance pulmonary arteries is matched to alveolar ventilation. This …
A new metabotropic role for L-type Ca2+ channels in vascular smooth muscle contraction
J Urena, M Fernandez-Tenorio… - Current vascular …, 2013 - ingentaconnect.com
Vascular smooth muscle cells (VSMCs) contraction can be evoked by the rise of cytosolic
[Ca2+] owing to transmembrane Ca2+ influx or sarcoplasmic reticulum (SR) Ca2+ release …
[Ca2+] owing to transmembrane Ca2+ influx or sarcoplasmic reticulum (SR) Ca2+ release …
Metabolic syndrome inhibits store-operated Ca2+ entry and calcium-induced calcium-release mechanism in coronary artery smooth muscle
B Climent, E Santiago, A Sánchez… - Biochemical …, 2020 - Elsevier
Background and purpose Metabolic syndrome causes adverse effects on the coronary
circulation including altered vascular responsiveness and the progression of coronary artery …
circulation including altered vascular responsiveness and the progression of coronary artery …
[HTML][HTML] Mitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction
J Zhou, J Zhang, Y Lu, S Huang, R Xiao, X Zeng… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hypoxia triggers pulmonary vasoconstriction, however induces relaxation of systemic
arteries such as femoral arteries. Mitochondria are functionally and structurally …
arteries such as femoral arteries. Mitochondria are functionally and structurally …
Urocortin‐2 induces vasorelaxation of coronary arteries isolated from patients with heart failure
T Smani, E Calderon… - Clinical and …, 2011 - Wiley Online Library
Urocortin‐2 (Ucn2) is a vasoactive peptide belonging to the corticotrophin‐releasing factor
(CRF) family that has potent cardiovascular actions. It has been suggested that Ucn2 …
(CRF) family that has potent cardiovascular actions. It has been suggested that Ucn2 …
The electrophysiological effects of Tongyang Huoxue granules on the ignition phase during hypoxia/reoxygenation injury in sinoatrial node cells
Q Wu, X Chang, Y Wang, J Liu, X Guan, Z Liu… - Frontiers in …, 2024 - frontiersin.org
Introduction This study was undertaken to explore the potential therapeutic effects of
Tongyang Huoxue Granules (TYHX) on sinoatrial node (SAN) dysfunction, a cardiac …
Tongyang Huoxue Granules (TYHX) on sinoatrial node (SAN) dysfunction, a cardiac …
Genetic Ablation of L-Type Ca2+ Channels Abolishes Depolarization-Induced Ca2+ Release in Arterial Smooth Muscle
M Fernández-Tenorio, P González-Rodríguez… - Circulation …, 2010 - Am Heart Assoc
Rationale: In arterial myocytes, membrane depolarization-induced Ca2+ release (DICR)
from the sarcoplasmic reticulum (SR) occurs through a metabotropic pathway that leads to …
from the sarcoplasmic reticulum (SR) occurs through a metabotropic pathway that leads to …
Role of Orai1 and L-type CaV1. 2 channels in Endothelin-1 mediated coronary contraction under ischemia and reperfusion
EM Calderón-Sánchez, J Ávila-Medina… - Cell Calcium, 2020 - Elsevier
Abstract Ischemia and Reperfusion (I/R) injuries are associated with coronary artery
hypercontracture. They are mainly originated by an exacerbated response to agonists …
hypercontracture. They are mainly originated by an exacerbated response to agonists …
Aging reduces L-type calcium channel current and the vasodilatory response of small mesenteric arteries to calcium channel blockers
Calcium channel blockers (CCBs) are widely used to treat cardiovascular disease (CVD)
including hypertension. As aging is an independent risk factor for CVD, the use of CCBs …
including hypertension. As aging is an independent risk factor for CVD, the use of CCBs …