Background: Sustained vascular smooth muscle contraction is mediated by extracellular
Ca2+ influx through L-type voltage-gated Ca2+ channels (VGCC) and RhoA/Rho …

Hypoxic pulmonary vasoconstriction (HPV) is an important mechanism by which localized
flow of blood in small resistance pulmonary arteries is matched to alveolar ventilation. This …

Vascular smooth muscle cells (VSMCs) contraction can be evoked by the rise of cytosolic
[Ca2+] owing to transmembrane Ca2+ influx or sarcoplasmic reticulum (SR) Ca2+ release …

Background and purpose Metabolic syndrome causes adverse effects on the coronary
circulation including altered vascular responsiveness and the progression of coronary artery …

Hypoxia triggers pulmonary vasoconstriction, however induces relaxation of systemic
arteries such as femoral arteries. Mitochondria are functionally and structurally …

Urocortin‐2 (Ucn2) is a vasoactive peptide belonging to the corticotrophin‐releasing factor
(CRF) family that has potent cardiovascular actions. It has been suggested that Ucn2 …

Introduction This study was undertaken to explore the potential therapeutic effects of
Tongyang Huoxue Granules (TYHX) on sinoatrial node (SAN) dysfunction, a cardiac …

Rationale: In arterial myocytes, membrane depolarization-induced Ca2+ release (DICR)
from the sarcoplasmic reticulum (SR) occurs through a metabotropic pathway that leads to …

Abstract Ischemia and Reperfusion (I/R) injuries are associated with coronary artery
hypercontracture. They are mainly originated by an exacerbated response to agonists …

Calcium channel blockers (CCBs) are widely used to treat cardiovascular disease (CVD)
including hypertension. As aging is an independent risk factor for CVD, the use of CCBs …