Central precocious puberty results from the premature activation of the hypothalamic-
pituitary-gonadal axis. It mimics physiological pubertal development, although at an …

The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

This update, written by authors designated by multiple pediatric endocrinology societies
(see List of Participating Societies) from around the globe, concisely addresses topics …

Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain
challenging due to lack of standardization. The aim of this revision was to address the …

GnRH analogues (GnRHa) are the treatment of choice for central precocious puberty (CPP),
with the main objective to recover the height potential compromised by the premature fusion …

Central precocious puberty (CPP) is a diagnosis that pediatric endocrinologists worldwide
increasingly make in girls of age 6-8 years and is mostly idiopathic. Part of the reason for …

Background/Aims Central precocious puberty (CPP) is due to premature activation of the
hypothalamic-pituitary-gonadal axis. It predominantly affects girls. CPP leads to lower final …

In this review several aspects of gonadotrophin releasing hormone agonists (GnRHa)
treatment in central precocious puberty (CPP) are highlighed. These include issues of the …

OBJECTIVES: The aim of this study is to present a survey of vulnerabilities and to suggest
approaches for the treatment of rare diseases according to the perceptions of a group of …

Context Gonadotropin-releasing hormone analogues (GnRHa) and recombinant human
growth hormone (rhGH) have been widely used to treat idiopathic central precocious …