Transferrin (Tf) is an essential protein, probably ubiquitous to all metazoans. The main
function of this family of proteins is to bind and transport ferric ions, increasing Fe (III) …

Parkinson's disease is caused by a complex interplay of genetic and environmental factors.
Although a number of independent molecular pathways and processes have been …

Optimization of the systems for active-targeting drug delivery is a pending task in view of
more directed transport of the active components to neoplastic cells. One of the ways to …

A novel biomimetic drug delivery system (BDDS) inspired by the pH-dependent ferric ion-
transport and release manner of transferrin (Tf) was developed for combating multidrug …

Iron-based metal-organic frameworks (MIL (101)) have recently gained attention in materials
science for biomedical applications. In the present work, Iron-based MOF (MIL-101 (Fe)) …

Dihydrofolate reductase (DHFR) is an important drug target and a highly studied model
protein for understanding enzyme dynamics. DHFR's crucial role in folate synthesis renders …

Conformational changes play a key role in the biological function of many proteins, thereby
sustaining a multitude of processes essential to life. Thus, the imaging of the conformational …

Influenza A virus (IAV) infection is commonly complicated by secondary bacterial infections
that lead to increased morbidity and mortality. Our recent work demonstrates that IAV …

Genetically encoded fluorescent biosensors (GEFBs) proved to be reliable tracers for many
metabolites and cellular processes. In the simplest case, a fluorescent protein (FP) is …

Dihydrofolate reductase (DHFR) is a ubiquitous enzyme with an essential role in cell
metabolism. DHFR catalyzes the reduction of dihydrofolate to tetrahydrofolate, which is a …