The application of the CRISPR-Cas system in antibiotic resistance

S Tao, H Chen, N Li, W Liang - Infection and drug resistance, 2022 - Taylor & Francis
The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …

Novel strategy to combat antibiotic resistance: a sight into the combination of CRISPR/Cas9 and nanoparticles

F Wan, MS Draz, M Gu, W Yu, Z Ruan, Q Luo - Pharmaceutics, 2021 - mdpi.com
Antibiotic resistance is a significant crisis that threatens human health and safety worldwide.
There is an urgent need for new strategies to control multidrug-resistant (MDR) bacterial …

Inverse association between the existence of CRISPR/Cas systems with antibiotic resistance, extended spectrum β-lactamase and carbapenemase production in …

NA Jwair, MTS Al-Ouqaili, F Al-Marzooq - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance, with the production of extended-spectrum β-lactamases (ESBL)
and carbapenemases, is common in the opportunistic pathogen, Klebsiella pneumoniae …

Prevalence of CRISPR-Cas Systems and Their Possible Association with Antibiotic Resistance in Enterococcus faecalis and Enterococcus faecium Collected from …

AHM Alduhaidhawi, SN AlHuchaimi… - Infection and Drug …, 2022 - Taylor & Francis
Purpose This study aimed to evaluate the presence of CRISPR-Cas system genes and their
possible association with antibiotic resistance patterns of Enterococcus faecalis and …

Drug resistance: An incessant fight against evolutionary strategies of survival

F Ramos-Martín, N D'amelio - Microbiology Research, 2023 - mdpi.com
The inherent capacity of all organisms to evolve under selective pressure has created
multidrug-resistant microbes and cells that are now threatening decades of progress in …

[HTML][HTML] CRISPR-cas system: An adaptive immune system's association with antibiotic resistance in Salmonella enterica serovar Enteritidis

MZ Haider, MAB Shabbir, T Yaqub… - BioMed Research …, 2022 - ncbi.nlm.nih.gov
Several factors are involved in the emergence of antibiotic-resistant bacteria and pose a
serious threat to public health safety. Among them, clustered regularly interspaced short …

Correlation of CRISPR/Cas and Antimicrobial Resistance in Klebsiella pneumoniae Clinical Isolates Recovered from Patients in Egypt Compared to Global Strains

AK Alkompoz, SM Hamed, ASA Zaid, TA Almangour… - Microorganisms, 2023 - mdpi.com
The CRISPR/Cas system has been long known to interfere with the acquisition of foreign
genetic elements and was recommended as a tool for fighting antimicrobial resistance. The …

Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based on Quorum Sensing (QS) Signal-Response System and Innovative Non-Antibiotic …

E Juszczuk-Kubiak - International Journal of Molecular Sciences, 2024 - mdpi.com
One of the key mechanisms enabling bacterial cells to create biofilms and regulate crucial
life functions in a global and highly synchronized way is a bacterial communication system …

Role of CRISPR-Cas systems and anti-CRISPR proteins in bacterial antibiotic resistance

H Kadkhoda, P Gholizadeh, HS Kafil, R Ghotaslou… - Heliyon, 2024 - cell.com
The emergence and development of antibiotic resistance in bacteria is a serious threat to
global public health. Antibiotic resistance genes (ARGs) are often located on mobile genetic …

Distribution characteristics of the Legionella CRISPR-Cas system and its regulatory mechanism underpinning phenotypic function

PX Xu, HY Ren, N Zhao, XJ Jin, BH Wen… - Infection and …, 2024 - Am Soc Microbiol
Legionella is a common intracellular parasitic bacterium that infects humans via the
respiratory tract, causing Legionnaires' disease, with fever and pneumonia as the main …