Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …

The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Macrophages exposed to inflammatory stimuli including LPS undergo metabolic
reprogramming to facilitate macrophage effector function. This metabolic reprogramming …

Tracking the immune microenvironment of tumours is essential for understanding the
mechanisms behind the effectiveness of cancer immunotherapies. Molecular imaging of …

Increasing evidence indicates that immunotherapy is hindered by a hostile tumor
microenvironment (TME) featured with deprivation of critical nutrients and pooling of …

Glioblastoma multiforme (GBM) is an aggressive brain cancer with a poor prognosis and few
treatment options. Here, building on the observation of elevated lactate (LA) in resected …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

The most immune cells infiltrating tumor microenvironment (TME), tumor‐associated
macrophages (TAMs) closely resemble immunosuppressive M2‐polarized macrophages …

Tumor cells undergoing immunogenic cell death (ICD) release immunogenic damage-
associated molecular patterns (DAMPs) to trigger a long-term protective antitumor response …