The dual role of citrate in cancer

P Icard, L Simula, G Zahn, M Alifano… - Biochimica et Biophysica …, 2023 - Elsevier
Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where
it performs several functions. In normal cells, citrate sustains protein acetylation, lipid …

Opportunities and challenges for inhibitors targeting citrate transport and metabolism in drug discovery

L Zhang, W Hu, Z Qiu, Z Li, J Bian - Journal of Medicinal …, 2023 - ACS Publications
Lipid metabolism disorder is closely related to metabolic diseases, inflammation, and
cancer. The concentration of citrate in the cytosol has a significant impact on lipid synthesis …

Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism

X Chi, Y Chen, Y Li, L Dai, Y Zhang, Y Shen… - Science …, 2024 - science.org
The solute carrier 13 (SLC13) family comprises electrogenic sodium ion–coupled anion
cotransporters, segregating into sodium ion–sulfate cotransporters (NaSs) and sodium ion …

The citrate transporter SLC13A5 as a therapeutic target for kidney disease: evidence from Mendelian randomization to inform drug development

D Gill, L Zagkos, R Gill, T Benzing, J Jordan… - BMC medicine, 2023 - Springer
Background Solute carrier family 13 member 5 (SLC13A5) is a Na+-coupled citrate co-
transporter that mediates entry of extracellular citrate into the cytosol. SLC13A5 inhibition …

Mapping the Metabolic Niche of Citrate Metabolism and SLC13A5

F Chen, HF Willenbockel, T Cordes - Metabolites, 2023 - mdpi.com
The small molecule citrate is a key molecule that is synthesized de novo and involved in
diverse biochemical pathways influencing cell metabolism and function. Citrate is highly …

[HTML][HTML] An Injectable silk-based hydrogel as a novel biomineralization seedbed for critical-sized bone defect regeneration

Y Zhu, H Gu, J Yang, A Li, L Hou, M Zhou, X Jiang - Bioactive Materials, 2024 - Elsevier
The healing process of critical-sized bone defects urges for a suitable biomineralization
environment. However, the unsatisfying repair outcome usually results from a disturbed …

[HTML][HTML] RNA expression changes driven by altered epigenetics status related to NASH etiology

D Castellano-Castillo, B Ramos-Molina… - Biomedicine & …, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a growing health problem due to the increased
obesity rates, among other factors. In its more severe stage (NASH), inflammation …

RNA‐Seq‐based discovery of genetic variants and allele‐specific expression of two layer lines and broiler chicken

MA Iqbal, F Hadlich, H Reyer, M Oster… - Evolutionary …, 2023 - Wiley Online Library
Recent advances in the selective breeding of broilers and layers have made poultry
production one of the fastest‐growing industries. In this study, a transcriptome variant calling …