The role of epistasis in the genetic architecture of quantitative traits is controversial, despite
the biological plausibility that nonlinear molecular interactions underpin the genotype …

Genome-wide association study (GWAS) has become a widely accepted strategy for
decoding genotype-phenotype associations in many species thanks to advances in next …

Many modern genomic data analyses require implementing regressions where the number
of parameters (p, eg, the number of marker effects) exceeds sample size (n). Implementing …

We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten
times more variants than previously known. We use these genomes to explore the …

We present PEER (probabilistic estimation of expression residuals), a software package
implementing statistical models that improve the sensitivity and interpretability of genetic …

Both linear mixed models (LMMs) and sparse regression models are widely used in
genetics applications, including, recently, polygenic modeling in genome-wide association …

Inbreeding depression—the reduced survival and fertility of offspring of related individuals—
occurs in wild animal and plant populations as well as in humans, indicating that genetic …

Although recent genome-wide studies have provided valuable insights into the genetic basis
of human disease, they have explained relatively little of the heritability of most complex …

US maize yield has increased eight-fold in the past 80 years, with half of the gain attributed
to selection by breeders. During this time, changes in maize leaf angle and size have altered …

We intuitively believe that the dramatic drop in the cost of DNA marker information we have
experienced should have immediate benefits in accelerating the delivery of crop varieties …