Unlike arsenic, chromium, or nickel, the carcinogenicity of iron is still under debate. In this
review, evidence for iron as a carcinogenic metal was summarized from epidemiological …

GENETIC IRON OVERLOAD disorders are prevalent yet poorly understood. Over the past 3
years, the discoveries of the hereditary hemochromatosis gene and an intestinal iron …

Hereditary hemochromatosis (HH) is a common autosomal recessive disorder causing
inappropriate dietary iron absorption that affects North Europeans. HH is associated with the …

Genetic hemochromatosis (GH) is believed to be a disease restricted to those of European
ancestry. In northwestern Europe,> 80% of GH patients are homozygous for one mutation …

Two HFE gene mutations, C282Y and H63D, underlie the vast majority of cases of
hereditary hemochromatosis. We performed a cross-sectional primary care-based study to …

Consanguineous populations of the Arabian Peninsula have been underrepresented in
global efforts that catalogue human exome variability. We sequenced 291 whole exomes of …

The C282Y mutation in theHFEgene is the main mutation causing hemochromatosis, and
C282Y frequencies have been reported for various European populations. The aim of this …

Proteins of Iron Metabolism presents a clear picture of the structure and function of the main
proteins involved in iron metabolism. The book gives you a detailed description of the …

Genetic hemochromatosis (GH) is closely associated with genes of the major
histocompatibility complex (MHC) on chromosome 6. Recently, a candidate gene for GH …

Abstract Background. Alpha-1-antitrypsin (A1AT) S and Z deficiency alleles and
hemochromatosis (HFE) mutant C282Y, H63D alleles were reported to potentially affect the …