This Minireview describes recent advances toward the synthesis of fluoro‐,
monofluoromethyl‐, difluoromethyl‐, and trifluoromethyl‐substituted three‐membered rings …

After more than 20 years of trials, a practical scalable approach to fluoro‐substituted bicyclo
[1.1. 1] pentanes (F‐BCPs) has been developed. The physicochemical properties of the F …

In recent years, fluoroiodomethane (CH2FI) has emerged as an easy-to-handle, non-ozone
depleting agent and readily available platform for monofluoromethylation strategies. Recent …

In the field of organic synthesis, the advent of flow chemistry and flow microreactor
technology represented a tremendous novelty in the way of thinking and performing …

The external quenching method based on flow microreactors allows the generation and use
of short‐lived fluoro‐substituted methyllithium reagents, such as fluoromethyllithium …

A straightforward flow synthesis of α-chloro aldehydes has been developed. The strategy
involves, for the first time, the thermal unstable chloroiodomethyllithium carbenoid and …

Abstract A formal CH2− CH2 homologation conducted with C1 carbenoids on a carbon
electrophile for the obtainment of a four‐membered cycle is reported. The logic proposes the …

The commercially available fluoroiodomethane represents a valuable and effective
electrophilic source for transferring the CH2F unit to a series of heteroatom-centered …

A direct nucleophilic monofluoroalkylation strategy leveraging on lithium fluorocarbenoids
has been developed. Flow microreactor technology allows capitalization of the synthetic …

There is considerable interest in incorporating fluorine into agrochemicals and
pharmaceuticals to improve their biological properties. Whilst a number of methods have …