Small molecules as chromatographic tools for HPLC enantiomeric resolution: Pirkle-type chiral stationary phases evolution

C Fernandes, ME Tiritan, M Pinto - Chromatographia, 2013 - Springer
This review focuses on the evolution of Pirkle-type chiral stationary phases (CSPs), based
on chiral recognition mechanism of small molecules and applications directly related with …

Chiral stationary phases based on small molecules: An update of the last 17 years

C Fernandes, YZ Phyo, AS Silva… - Separation & …, 2018 - Taylor & Francis
A literature survey covering the report on Pirkle-type chiral stationary phases (CSPs) from
January 2000 to March 2017 is presented in this review. More than 200 CSPs comprising …

Molecular dynamics study of chiral recognition for the Whelk-O1 chiral stationary phase

CF Zhao, NM Cann - Analytical chemistry, 2008 - ACS Publications
In this article, we examine the docking of 10 analytes on the Whelk-O1 stationary phase. A
proper representation of analyte flexibility is essential in the docking analysis, and analyte …

Enantioresolution of chiral derivatives of xanthones on (S, S)‐Whelk‐O1 and l‐phenylglycine stationary phases and chiral recognition mechanism by docking …

C Fernandes, A Palmeira, A Santos, ME Tiritan… - Chirality, 2013 - Wiley Online Library
The resolution of seven enantiomeric pairs of chiral derivatives of xanthones (CDXs) on (S,
S)‐Whelk‐O1 and l‐phenylglycine chiral stationary phases (CSPs) was systematically …

Modification of Kagan's amide for improved activity as Chiral Solvating Agent in enantiodiscrimination during NMR analysis

N Jain, AN Khanvilkar, S Sahoo, AV Bedekar - Tetrahedron, 2018 - Elsevier
A modification is proposed in Kagan's amide in order to improve its ability to offer stronger
hydrogen bonding and hence better ability to bind with substrates. Introduction of chlorine in …

Rational optimization of the Whelk-O1 chiral stationary phase using molecular dynamics simulations

CF Zhao, S Diemert, NM Cann - Journal of Chromatography A, 2009 - Elsevier
Rational in silico optimization of the Whelk-O1 chiral stationary phase (CSP) has been
carried out based on the chiral recognition mechanism extracted from previous molecular …

Application of roof-shape amines as chiral solvating agents for discrimination of optically active acids by NMR spectroscopy: study of match–mismatch effect and …

R Gupta, RG Gonnade, AV Bedekar - The Journal of Organic …, 2016 - ACS Publications
Optically active roof-shape amines were prepared and scanned as chiral solvating agents to
study molecular recognition of acids by NMR analysis. Three types of amines were studied …

Modified Kagan's amide: synthesis and application as a chiral solvating agent for hydrogen-bonding based chiral discrimination in NMR

N Jain, RB Patel, AV Bedekar - RSC Advances, 2015 - pubs.rsc.org
A modified Kagan's amide, N-((S)-1-(3, 5-bis (trifluoromethyl) phenyl) ethyl)-3, 5-
dinitrobenzamide [(S)-2] has been designed, synthesized and screened as a Chiral …

Synthesis And Study of Fluorine Containing Kagan's Amides as Chiral Solvating Agents For Enantiodiscrimination of Acids by NMR Spectroscopy

HB Raval, AV Bedekar - ChemistrySelect, 2020 - Wiley Online Library
The Kagan's amide is used as chiral solvating agent to discriminate the signals of optically
active analytes in NMR spectroscopy. Three fluorinated derivatives of this amide are …

[HTML][HTML] Enantioseparation of racemic bupivacaine via ultrasonic-assisted diastereomeric crystallization using 12, 14-dinitrodehydroabietic acid

L Ge, Y Zhu, Y Qi, Y Chen, K Yang - Ultrasonics Sonochemistry, 2019 - Elsevier
Dinitrodehydroabietic acid (12, 14-dinitroDHAA), a chiral acid obtained by the nitration of
optical dehydroabietic acid (DHAA), was successfully employed as resolving agent. The …