It has been nearly 10 years since the completion of the first entire genome sequence of a
Leishmania parasite. Genomic and transcriptomic analyses have advanced our …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Abstract The Leishmania tarentolae Parrot-TarII strain genome sequence was resolved to an
average 16-fold mean coverage by next-generation DNA sequencing technologies. This is …

Leishmania spp. are sandfly-transmitted parasitic protozoa that cause a spectrum of
important diseases and lifelong chronic infections in humans. In the mammalian host, these …

Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile
promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms …

Background Several eukaryotic parasites form cysts that transmit infection. The process is
found in diverse organisms such as Toxoplasma, Giardia, and nematodes. In Entamoeba …

Leishmaniasis is one of the major neglected tropical diseases, for which no vaccines exist.
Chemotherapy is hampered by limited efficacy coupled with development of resistance and …

Alphaproteobacteria show a great versatility in adapting to a broad range of environments
and lifestyles, with the association between bacteria and plants as one of the most intriguing …

Two major leishmaniasis treatments have shown a significant decrease in effectiveness in
the last few decades, mostly in the Indian subcontinent but also in other endemic areas …

A key factor in the successful infection of a mammalian host by Leishmania parasites is their
conversion from extracellular motile promastigotes into intracellular amastigotes. We discuss …