Zinc exacerbates tau pathology in a tau mouse model

KM Craven, WR Kochen… - Journal of Alzheimer's …, 2018 - content.iospress.com
Hyperphosphorylated tau protein is a key pathology in Alzheimer's disease (AD),
frontotemporal dementia, chronic traumatic encephalopathy, and Parkinson's disease. The …

The effects of enhanced zinc on spatial memory and plaque formation in transgenic mice

DH Linkous, PA Adlard, PB Wanschura… - Journal of …, 2009 - content.iospress.com
There is considerable evidence suggesting that metals play a central role in the
pathogenesis of Alzheimer's disease. Reports suggest that elevated dietary metals may both …

Neurobehavioral disorders induced by environmental zinc in female zebrafish (Danio rerio): Insights from brain and intestine transcriptional and metabolic signatures

F Yu, ZS Hou, HR Luo, HX Li, XF Cui, JL Li, WR Feng… - Chemosphere, 2023 - Elsevier
Human activities can cause zinc (Zn) contamination of aquatic environments. Zn is an
essential trace metal, but effects of environmentally relevant Zn exposure on the brain …

Maternal zinc supplementation improves spatial memory in rat pups

A Piechal, K Blecharz-Klin, J Pyrzanowska… - … Trace Element Research, 2012 - Springer
A large body of evidence supports an opinion that adequate dietary zinc is essential for
prenatal and postnatal brain development. Behavioural effects of maternal supplementation …

Alterations in fear response and spatial memory in pre-and post-natal zinc supplemented rats: remediation by copper

AM Railey, TL Micheli, PB Wanschura, JM Flinn - Physiology & behavior, 2010 - Elsevier
The role of zinc in the nervous system is receiving increased attention. At a time when
dietary fortification and supplementation have increased the amount of zinc being …

The effect of metals on spatial memory in a transgenic mouse model of Alzheimer's disease

AM Railey, CM Groeber… - Journal of Alzheimer's …, 2011 - content.iospress.com
The amyloid-β protein (Aβ) is a metalloprotein with affinity for the metal ions zinc (Zn),
copper (Cu), and iron (Fe), which are found in high concentrations in the plaques of …

Brain region-and metal-specific effects of embedded metals in a shrapnel wound model in the rat

JF Hoffman, VB Vergara, JF Kalinich - Neurotoxicology, 2021 - Elsevier
The health effects of prolonged exposure to embedded metal fragments, such as those
found in shrapnel wounds sustained by an increasing number of military personnel, are not …

Removal of inorganic trace contaminants by electrodialysis in a remote Australian community

LJ Banasiak, AI Schäfer - Desalination, 2009 - Elsevier
Water provision for developing countries is a critical issue as a vast number of lives are lost
annually due to lack of access to safe drinking water. The presence and fate of inorganic …

In vivo and in vitro analyses of amygdalar function reveal a role for copper

ED Gaier, RM Rodriguiz, J Zhou… - Journal of …, 2014 - journals.physiology.org
Mice with a single copy of the peptide amidating monooxygenase (Pam) gene (PAM+/−) are
impaired in contextual and cued fear conditioning. These abnormalities coincide with …

Influence of long-term zinc administration on spatial learning and exploratory activity in rats

A Piechal, K Blecharz-Klin, J Pyrzanowska… - Biological trace element …, 2016 - Springer
Animal brain contains a significant amount of zinc, which is a cofactor for more than 300
enzymes. Moreover, it provides the basis for functioning of more than 2000 transcription …