Cell cycle control in cancer
HK Matthews, C Bertoli, RAM de Bruin - Nature reviews Molecular cell …, 2022 - nature.com
Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …
division is tightly regulated by multiple evolutionarily conserved cell cycle control …
Tumour evolution in hepatocellular carcinoma
AJ Craig, J Von Felden, T Garcia-Lezana… - Nature reviews …, 2020 - nature.com
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically
develops on the background of chronic liver disease and is an aggressive disease with …
develops on the background of chronic liver disease and is an aggressive disease with …
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects
DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that
is thought to explain their exceptional responsiveness to immune checkpoint blockade …
is thought to explain their exceptional responsiveness to immune checkpoint blockade …
[HTML][HTML] Non-cell-autonomous cancer progression from chromosomal instability
Chromosomal instability (CIN) is a driver of cancer metastasis,,–, yet the extent to which this
effect depends on the immune system remains unknown. Using ContactTracing—a newly …
effect depends on the immune system remains unknown. Using ContactTracing—a newly …
Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes
Single-cell transcriptomic analysis is widely used to study human tumors. However, it
remains challenging to distinguish normal cell types in the tumor microenvironment from …
remains challenging to distinguish normal cell types in the tumor microenvironment from …
Persistent mutation burden drives sustained anti-tumor immune responses
Tumor mutation burden is an imperfect proxy of tumor foreignness and has therefore failed
to consistently demonstrate clinical utility in predicting responses in the context of …
to consistently demonstrate clinical utility in predicting responses in the context of …
Signatures of copy number alterations in human cancer
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
Pan-cancer whole-genome comparison of primary and metastatic solid tumours
F Martínez-Jiménez, A Movasati, SR Brunner… - Nature, 2023 - nature.com
Metastatic cancer remains an almost inevitably lethal disease,–. A better understanding of
disease progression and response to therapies therefore remains of utmost importance …
disease progression and response to therapies therefore remains of utmost importance …
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers
Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity
and accelerated tumor evolution,–; however, its frequency and clinical impact are unclear …
and accelerated tumor evolution,–; however, its frequency and clinical impact are unclear …
Cancer aneuploidies are shaped primarily by effects on tumour fitness
J Shih, S Sarmashghi, N Zhakula-Kostadinova… - Nature, 2023 - nature.com
Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …