Breast cancer is a complex and diverse condition that disrupts multiple signaling pathways
essential for cell proliferation, survival, and differentiation. Recently, the significant …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Sustaining neuronal proteostasis during the course of our life is a central aspect required for
brain function. The dynamic nature of synaptic composition and abundance is a requisite to …

In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …

Insulin-like growth factor 2 (IGF2) emerged as a critical mechanism of synaptic plasticity and
learning and memory. Deficits in IGF2 in the brain, serum, or cerebrospinal fluid (CSF) are …

Several neurological diseases share pathological alterations, even though they differ in their
etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress …

The identification of molecular biomarkers in CSF from individuals affected by Huntington
disease may help improve predictions of disease onset, better define disease progression …

The aging process is characterized by a progressive decline in the function of most tissues,
representing the main risk factor in the development of a variety of human diseases. Studies …

Insulin-like growth factor 2 (IGF2) and autophagy-related genes have been proposed as
biomolecules of interest related to idiopathic Parkinson's disease (PD). The objective of this …

A number of studies performed on rodents suggest that insulin-like growth factor 2 (IGF-2) or
its analogs may possibly be used for treating some conditions like Alzheimer's disease …