Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through
the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites …

An essential step in the life cycle of malaria parasites is their egress from hepatocytes, which
enables the transition from the asymptomatic liver stage to the pathogenic blood stage of …

Plasmodium sporozoites that are transmitted by blood-feeding female Anopheles
mosquitoes invade hepatocytes for an initial round of intracellular replication, leading to the …

The most severe form of human malaria is caused by Plasmodium falciparum. Its virulence is
closely linked to the increase in rigidity of infected erythrocytes and their adhesion to …

Malaria parasites in the blood stage express a single transmembrane transport protein for
the release of the glycolytic end product l-lactate/H+ from the cell. This transporter is a …

Plasmodium malaria parasites are obligate intracellular protozoans that use a unique form
of locomotion, termed gliding motility, to move through host tissues and invade cells. The …

Over recent years, a plethora of new genetic tools has transformed conditional engineering
of the malaria parasite genome, allowing functional dissection of essential genes in the …

Plasmodium parasites have a complex life cycle that includes development in the human
host as well as the Anopheles vector. Successful transmission of the parasite between its …

Apicomplexan parasites encompass diverse pathogens for humans and animals, including
the causative agents of malaria and toxoplasmosis, Plasmodium spp. and Toxoplasma …

Novel antimalarial compounds targeting both the pathogenic and transmissible stages of the
human malaria parasite, Plasmodium falciparum, would greatly benefit malaria elimination …