Sex steroids are major promoters of the growth of breast and prostate cancers. This Review
by Poutanen et al. describes the development of treatments for these cancer types that act to …

Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary …

Microglia and astrocytes play essential roles in the maintenance of homeostasis within the
central nervous system, but mechanisms that control the magnitude and duration of …

Context: The human adrenal gland produces small amounts of testosterone that are
increased under pathological conditions. However, the mechanisms through which the …

Disturbed action of sex steroid hormones, ie androgens and estrogens, is involved in the
pathogenesis of various severe diseases in humans. Interestingly, recent studies have …

Abstract Background Brenner tumours (BTs), like other epithelial ovarian tumours, are
thought to develop from the ovarian surface epithelium. Aim and Methods We hypothesised …

Epithelial ovarian tumors are responsive to steroid hormone stimulation and the ovarian
stroma may have a direct role in this process. We evaluated immunohistochemical markers …

Carcinogenesis of hormone-related cancers involves hormone-stimulated cell proliferation,
which increases the number of cell divisions and the opportunity for random genetic errors …

Background The majority of acute myeloid leukaemia (AML) patients are over sixty years of
age. With current treatment regimens, survival rates amongst these, and also those younger …

Despite the extensive research during the last six decades the fundamental questions
concerning the role of steroids in the initiation of human parturition and origin and function of …