The immune system maintains a critically organized network to defend against foreign
particles, while evading self-reactivity simultaneously. T lymphocytes function as effectors …

Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

Type 1 conventional dendritic cells (cDC1s) are typically thought to be dysregulated
secondarily to invasive cancer. Here, we report that cDC1 dysfunction instead develops in …

The receptor programmed death 1 (PD-1) inhibits T cell proliferation and plays a critical role
in suppressing self-reactive T cells, and it also compromises antiviral and antitumor …

Strategies to activate and rescue exhausted tumor-specific T cells, including the use of
monoclonal antibodies (mAb) that block the negative costimulatory receptors CTLA-4 and …

Photodynamic therapy (PDT) is a potentially immunogenic and FDA‐approved antitumor
treatment modality that utilizes the spatiotemporal combination of a photosensitizer, light and …

Background The increasing incidence and poor outcome associated with MPM requires
finding effective treatment for this disease. PD1/PD-L1 pathway plays a central role in tumor …

Over the past decade, immune-checkpoint inhibitors (ICIs) have revolutionized the treatment
of cancer. In mesothelioma, a rare cancer with a dismal prognosis generally caused by …

Maintenance of peripheral tolerance is essential for homeostasis of the immune system.
While central tolerance mechanisms result in deletion of the majority of self-reactive T cells …

Immune checkpoint blockades, such as inhibitors against programmed death 1 (PD-1) and
its ligand (PD-L1), have received extensive attention in the past decade because of their …