New insights into rosacea pathophysiology: a review of recent findings

M Steinhoff, J Schauber, JJ Leyden - Journal of the American Academy of …, 2013 - Elsevier
Rosacea is a common, chronic inflammatory skin disease of poorly understood origin.
Based on its clinical features (flushing, chronic inflammation, fibrosis) and trigger factors, a …

The molecular pathology of rosacea

K Yamasaki, RL Gallo - Journal of dermatological science, 2009 - Elsevier
Rosacea is a common and chronic inflammatory skin disease that affects over 10 million
Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all …

Redox regulation of cell migration and adhesion

TR Hurd, M DeGennaro, R Lehmann - Trends in cell biology, 2012 - cell.com
Reactive oxygen species (ROS), particularly hydrogen peroxide, and the proteins that
regulate them play important roles in the migration and adhesion of cells. Stimulation of cell …

Interaction of pattern recognition receptors with Mycobacterium tuberculosis

E Mortaz, IM Adcock, P Tabarsi, MR Masjedi… - Journal of clinical …, 2015 - Springer
Tuberculosis (TB) is considered a major worldwide health problem with 10 million new
cases diagnosed each year. Our understanding of TB immunology has become greater and …

The many roles of NOX2 NADPH oxidase-derived ROS in immunity

GY Lam, J Huang, JH Brumell - Seminars in immunopathology, 2010 - Springer
Reactive oxygen species (ROS) have long been studied in the context of their direct toxic
effects on cells. As a result, ROS have conventionally been thought of as a necessary …

[HTML][HTML] Rosacea: the cytokine and chemokine network

PA Gerber, BA Buhren, M Steinhoff, B Homey - Journal of Investigative …, 2011 - Elsevier
Rosacea is one of the most common dermatoses of adults. Recent studies have improved
our understanding of the pathophysiology of rosacea. Current concepts suggest that known …

Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia

S Hu, WS Sheng, SJ Schachtele… - Journal of …, 2011 - Springer
Background Production of reactive oxygen species (ROS) and proinflammatory cytokines by
microglial cells in response to viral brain infection contributes to both pathogen clearance …

[HTML][HTML] Host-mycobacteria conflict: Immune responses of the host vs. the mycobacteria TLR2 and TLR4 ligands and concomitant host-directed therapy

KP Pattanaik, S Sengupta, BP Jit, R Kotak… - Microbiological …, 2022 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the most grievous
infectious diseases with long-term morbidity and unpredicted mortality rates globally. Thus …

Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria

HM Lee, J Kang, SJ Lee, EK Jo - Glia, 2013 - Wiley Online Library
The inflammasome is a multimolecular complex that orchestrates the activation of
proinflammatory caspases and interleukin (IL)‐1β, which is generally increased in the …

Early secreted antigenic target of 6 kDa (ESAT-6) protein of Mycobacterium tuberculosis induces interleukin-8 (IL-8) expression in lung epithelial cells via protein …

V Boggaram, KR Gottipati, X Wang, B Samten - Journal of Biological …, 2013 - ASBMB
Early secreted antigenic target of 6 kDa (ESAT-6) of Mycobacterium tuberculosis is critical
for the virulence and pathogenicity of M. tuberculosis. IL-8, a major chemotactic cytokine for …